After four to six months of regular benzodiazepine use, there is little evidence of continued efficacy.

Lorazepam may also inhibit foetal liver bilirubin glucuronidation, leading to neonatal jaundice. Follow the directions on your prescription label. Paradoxical effects are more likely to occur with higher doses, in patients with pre-existing personality disorders and those with a psychiatric illness. Your symptoms may return when you stop using Ativan after using it over a long period of time. Due to the development of tolerance to the anticonvulsant effects, benzodiazepines are generally not recommended for long-term use for the management of epilepsy. This list is not complete and there may be other drugs that can interact with Ativan. Lorazepam should, therefore, not be prescribed in high doses or as the sole treatment in depression, but only with an appropriate antidepressantspecify. FDA pregnancy category D. Ativan may be habit-forming and should be used only by the person it was prescribed for. In cases of a suspected lorazepam overdose, it is important to establish whether the patient is a regular user of lorazepam or other benzodiazepines, since regular use causes tolerance to develop.